Liver and Kidneys Disease

Please click on the ‘Play’ button below to hear a short message from Dr. Zahra Figueredo about how she treats liver and kidney disease with her unique stem cell therapy.

HOW CAN STEM CELL THERAPY HELP WITH LIVER DISEASE?

 
The liver is one of the most important organs in the body, and it performs numerous essential functions. The liver is a large, rust-colored organ located in the upper right quadrant of the abdomen. It is essential to the maintenance of the body’s overall health.  One of the most important things the liver does is filter the blood and get rid of toxins and other dangerous substances. It also makes bile, which helps break down fats and helps the body digest food.  It is the body’s primary and most important detoxifying organ, the second being the skin. The liver is also in charge of keeping and releasing glucose as needed, making proteins that help the blood clot, and controlling the amount of cholesterol in the blood.

A number of issues can arise from an unhealthy liver.  The Fatty Liver disease, such as cirrhosis, hepatitis, and liver cancer are just a few of the most common liver health problems. These conditions can be caused by many things, like excess alcohol consumption, viruses or taking medications and street drugs. Over time, these situations can cause the liver to scar, which can compromise its function.  Liver failure, which can be life-threatening, can happen in the worst cases.

Scientists are looking into new ways to treat liver health problems, such as stem cell therapy. Stem cells can differentiate into many different types of cells, including liver cells, and can be used to fix, grow back and regenerate damaged liver tissue.  Recent studies have demonstrated the therapeutic effects of stem cells to treat liver fibrosis (build-up of scar tissue) and other acute and chronic liver diseases (‘The therapeutic effects of stem cells have been proved in chronic liver diseases  such as ALD, NAFLD and acute liver failure’).

We at SCHI employ our unprecedented technique of injecting our proprietary stem cell cocktail directly into the liver and kidney circulation and sometimes into the organ itself.  This allows for the stem cells to be allocated directly into the target tissues.

In conclusion, the liver is a very important organ that is a key part of keeping the body healthy and well due to its function in detoxifying the body.  Even though liver health problems can be dangerous if they aren’t handled, new treatments like stem cell therapy give people with liver disease hope that they can get better and get their liver function back enhancing their quality of life.

HOW CAN STEM CELL THERAPY HELP WITH KIDNEY DISEASE?

Stem cells, in general, are chemically attracted to injured areas of the body as injured tissues release a class of so-called chemical messengers called cytokines.
In the case of kidney disease, the kidneys will release cytokines specific to the kidneys to draw the stem cells to the kidney. The stem cells then regenerate and differentiate into the specific renal cells that are required for regeneration and repair the damaged tissue, such as parenchymal and glomeruli cells as well as aides in angiogenesis (production of new blood vessels).  Once the micro-circulation of the kidneys is restored, this lowers the blood pressure of the glomerulus. This, in turn, relieves the ischemia in the kidneys and therefore contribute to overall improvement of blood filtration and circulation.

In cases of kidney disease secondary to autoimmune disease, along with enhancing immunity, stem cells are deployed in order to potentially eliminate the autoimmunity by inhibiting T-Cells and modulating the immune system to work normally.

Kidney regeneration with stem cells is a promising strategy aimed at reducing the progression to end-stage renal disease (ESRD) and improving the quality of life of patients with ESRD.  The efficacy of mesenchymal stem cells (MSCs) in the recovery of kidney function has been demonstrated in nephropathy such as acute tubular injury, glomerulonephritis, renal artery stenosis, and remnant kidney.
MSCs not only secrete bioactive molecules directly into the circulation, but they also release various molecules, such as proteins, mRNA, microRNA, in membrane-covered vesicles.  Stem cell treatment enables bona fide kidney regeneration rather than kidney repair using remnant renal parenchymal cells.

  • RESEARCH REFERENCES
    1. Stem cell therapies for liver failure and cirrhosis

    Journal of Hepatology , Volume 59 , Issue 1 , 183 – 185

    Zhang, Zheng et al.

    1. Stem Cells and Liver Regeneration

    Gastroenterology. 2009 Aug; 137(2): 466–481.

    Published online 2009 May 24. doi:  10.1053/j.gastro.2009.05.044

    Duncan, Andrew W. et al.

     

    1. The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem Cells

    Tao Du 1 , 2 and Ying-Jian Zhu 

     

    1. Adult stem cells as a tool for kidney regeneration.

    Suzuki E1, Fujita D1, Takahashi M1, Oba S1, Nishimatsu H1

    World J Nephrol. 2016 Jan 6;5(1):43-52. doi: 10.5527/wjn.v5.i1.43.
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